New for 2023, this online event will provide researchers with an opportunity to learn about how spatial biology is helping us to gain a deeper understanding of molecular biology and mechanisms of disease. Speakers will discuss advances in spatial technologies and how they are being applied to provide a more complete picture of cells and complex biological systems in areas such as cancer research and neuroscience.

This webinar will introduce a novel method for parent-of-origin-aware genomic analysis using the long-read capabilities of nanopore sequencing and single-cell DNA template strand sequencing to assign variants to each biological parent with 99% accuracy using only a blood research sample from the child.

Protein stability is one of the most important critical quality attributes for a new biological drug. Unstable or misfolded proteins are prone to aggregation and precipitation, which can lead to lower activity as well as increased immunogenicity. There has been a long-standing interest in renaturing unfolded, misfolded or precipitated proteins.

In this webinar, our expert speakers will demonstrate how thermal and pressure stress changed the structure and melting point of two model proteins and resulted in the discovery of different structural rearrangements.

They will then discuss a novel method for solubilizing and refolding proteins using hydrostatic pressure to generate proteins whose structure matches that of the native protein, as confirmed by microfluidic modulation spectroscopy.

Using the example of tumor-associated macrophages (TAMs), this webinar takes a closer look at immune cells in the tumor microenvironment (TME), helping us to gain a better understanding of how specific subtypes and their reprogramming may influence therapy efficiency.

Cancer cells engage in intricate interactions with neighboring cancerous and stromal cells through direct cell-to-cell contact and paracrine signaling. Long-range communication with distant organ sites is facilitated by extracellular vesicles, as well as signaling molecules like cytokines, hormones and growth factors .

In this webinar, you will learn about the OGM workflow and how it can be applied to cell and gene therapy R&D, with emphasis on how it can significantly improve the quality, safety and overall risk profile of next-generation therapies.