Therapeutic Delivery – Webinars and Online Events

This webinar highlights the latest affinity chromatography solutions for the quick and easy purification of multiple AAV serotypes across a variety of column setups.

In recent years we’ve seen a steep rise in the application of nanomedicine, particularly with the use of viral and non-viral delivery vectors for nucleic acids, for use in vaccine development and cell and gene therapy.

Detailed and sensitive characterization of ionizable lipids that make up lipid nanoparticles (LNP) and their related impurities is necessary to ensure the quality of mRNA therapies. Additionally, there are mRNA quality attributes such as 5’ capping that directly impact efficacy and safety.

The Problem
LNPs are a valuable tool in the repertoire of gene and vaccine delivery vectors but LNP development is a complex multi-step process.

Speaking at the Advances in Drug Discovery & Development 2022 online symposium, Adam Crowe from SCIEX discussed how an ionizable lipid was analyzed with liquid chromatography coupled with mass spectrometry.

During this webinar, you will understand how capillary electrophoresis (CE) and LC-MS are being used to ensure vaccine and cell and gene therapy product quality. We will discuss how LC-MS is being used to identify impurities present in lipid nanoparticle (LNP) vaccines that have been found to deactivate mRNA. We will also cover how CE is being used in viral vector production to ensure product quality.

Although the primary focus of the pharmaceutical industry has been identifying the mechanisms of drug elimination and potential drug liability, there is now an increasing focus on the kidney as a therapeutic target.

Join Dr Natalia Sannikova and Tomas Skrinskas from Ascension Sciences, as they explore the therapeutic use of cannabinoids as novel medicines and the opportunities of nanotechnology in formulating cannabinoid nanoparticles.

Lipid nanoparticle (LNP) technology is increasingly enabling the clinical potential of genetic drugs. By packaging the nucleic acid polymer in well-defined nanoparticles, LNPs protect the nucleic acid payload in vivo and facilitate intracellular delivery following uptake into target cells by endocytosis.