Neurodegeneration – Multimedia

Your weekly science news roundup is here.

This poster demonstrates how a novel, precise and highly controlled iPSC reprogramming technology overcomes these limitations and enables the generation of mature cell types and isogenic models of neurodegenerative disease.

Microglia play key roles in neurogenesis, synaptic remodeling, and are the first responders to infection in the brain. Hence, disease-relevant cell models are key to the success of neuroimmune and neurodegeneration research.

Human iPSC-derived excitatory neurons provide helpful physiologically relevant cell models to investigate neurodevelopmental and neurodegenerative disorders, although achieving healthy neuronal cultures can be challenging.

Patient-derived induced pluripotent stem cells (iPSCs) enable generation of in vitro models that can recapitulate human disease phenotypes. However, conventional human iPSC differentiation protocols are often lengthy, inconsistent and difficult to scale.

To overcome these challenges, researchers have developed a proprietary gene-expression targeting strategy that can rapidly reprogram hiPSCs into pure somatic cell types in a scalable manner. This approach was used to develop a Huntington’s disease (HD) model carrying a 50CAG expansion in the huntingtin (HTT) gene.

Speaking at ‘Advances in Proteomics & Metabolomics’ 2022, Erik Johnson from Emory University, presented their talk on proteomics in Alzheimer’s disease.

Download this infographic to explore why cell signaling is important, how Wnt signaling is involved in cancer and the role of the JAK/STAT pathway in neurodegenerative disease.

In this video, Jonathan from the Institute of Human Anatomy discusses how Viagra works to assist with erectile dysfunction.

In this episode, we speak with Andris Abramenkovs, product manager of CellCelector technology at Sartorius.