Fundamentals of Therapeutic Drug Monitoring: Definition, Importance and Methods

Listicle

Published: August 9, 2021

Michele Trott, PhD

Fundamentals of Therapeutic Drug Monitoring: Definition, Importance and Methods content piece image

Therapeutic drug monitoring (TDM) is the measurement of circulating concentrations of a drug to adjust its dosing regimen, so as to reach a defined target exposure associated with optimal efficacy and minimal toxicity. Samples are collected at a known time relative to the administration of the last dose. Early development of TDM is largely attributed to University of California researchers Lewis Sheiner and Stuart Beal, who created NONMEM, a software for pharmacokinetics modeling.

Download this listicle to discover answers to key questions such as:

Can therapeutic drug monitoring be used for all drugs?
Which drugs are currently monitored using TDM approaches?
What analytical methods are used for therapeutic drug monitoring?

Meet the Author

Michele Trott, PhD

Michele Trott holds a PhD in endocrinology from Lincoln University. She works as a freelance science writer and scientific content manager for Izon Science.