Drug Kinetics – Key Definitions
As biology presents ever-more challenging targets, those in the drug discovery field are pushing ahead with new tools to design or discover drugs that have optimal kinetics.
But how familiar are you with the key terms used by scientists performing kinetics-directed drug design and discovery?
| Association rate constant is a second-order rate constant that defines the rate at which a free ligand and free receptor form a binary ligand–receptor complex. |
| A closed system is a system in which the ligand and receptor “binding partners” are present at temporally invariant concentrations throughout an experimental measure. |
| Desolvation is the process in which water molecules surrounding a ligand are displaced to allow the interaction of the ligand with its target. |
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