Cell-to-Cell Communication in Cancer

Cancer cells engage in intricate interactions with neighboring cancerous and stromal cells through direct cell-to-cell contact and paracrine signaling. Long-range communication with distant organ sites is facilitated by extracellular vesicles, as well as signaling molecules like cytokines, hormones and growth factors . These signaling events play a vital role in cancer cell survival, metastasis and immune evasion. To effectively combat cancer initiation, progression and metastasis, it is imperative to comprehend how cancer cells communicate within their microenvironment and with distant organ sites. Recent breakthroughs in technologies such as single-cell sequencing, 3D organoid cultures, and intravital imaging have provided unprecedented insights into cancer cell communication at a granular, single-cell level. These advances underscore the significant impact of heterogeneity within tumor composition, microenvironment and vasculature, as well as individual patient responses. During this webinar, Dr. Holz will delve into the foundational concepts of cell-to-cell communication and shed light on pertinent studies and recent advancements, emphasizing their implications in our understanding of cancer cell biology. Attend this webinar to: • Discover the key signaling events in cancer cell communication • Uncover the role of the tumor microenvironment in cancer cell interactions • Learn about recent research advances in this field and their clinical implications Dr. Marina K Holz Professor of Cell Biology and Anatomy, Dean of the Graduate School of Biomedical Sciences New York Medical College