Age Biomarkers Produced from Smartphone Data

Researchers from Moscow Institute of Physics and Technology (MIPT) and the longevity biotech company GERO have shown that physical activity data acquired from wearables can be used to produce digital biomarkers of aging and frailty. The breakthrough demonstration untaps the emerging potential of combining wearable sensors and AI technologies for continuous health risk monitoring with real-time feedback to life & health insurance, healthcare and wellness providers. The paper was published in Scientific Reports.

Many physiological parameters demonstrate tight correlations with age. Various biomarkers of age, such as DNA methylation, gene expression or circulating blood factor levels could be used to build accurate "biological clocks" to obtain individual biological age and the rate of aging estimations. Yet large-scale biochemical or genomic profiling is still logistically difficult and expensive for any practical applications beyond academic research.

The recent introduction of affordable wearable sensors enables collection and cloud-storing of personal digitized activity records. This tracking is already done without interfering with the daily routines of hundreds of millions of people all over the world.

Peter Fedichev, Ph.D., the head of the Laboratory of Biological Systems Simulation at MIPT, GERO Science Director, explains: "Artificial Intelligence is a powerful tool in pattern recognition and has demonstrated outstanding performance in visual object identification, speech recognition, and other fields. Recent promising examples in the field of medicine include neural networks showing cardiologist-level performance in detection of the arrhythmia in ECG data, deriving biomarkers of age from clinical blood biochemistry, and predicting mortality based on electronic medical records. Inspired by these examples, we explored AI potential for Health Risks Assessment based on human physical activity".

Researchers have analyzed physical activity records and clinical data from a large 2003–2006 US National Health and Nutrition Examination Survey (NHANES). They trained the neural network to predict biological age and mortality risk of the participants from the one-week long stream of activity measurements. A state-of-the-art Convolution Neural Network was used to unravel the most biologically relevant motion patterns and establish their relation to general health and recorded lifespan. A novel AI-based algorithm created by scientists has outperformed any previously available models of biological age and mortality risks from the same data.

"Life and health insurance programs have already begun to provide discounts to their users based on physical activity monitored by fitness wristbands. We report that AI can be used to further refine the risks models. Combination of aging theory with the most powerful modern machine learning tools will produce even better health risks models to mitigate longevity risks in insurance, help in pension planning, and contribute to upcoming clinical trials and future deployment of anti-aging therapies" — concludes Peter Fedichev.

The scientific team has already developed a free beta-version of an iPhone application Gero Lifespan estimating user’s lifespan with the help of the built-in smartphone accelerometer.

This article has been republished from materials provided by the Moscow Institute of Physics and Technology. Note: material may have been edited for length and content. For further information, please contact the cited source.

Reference: Pyrkov, T. V., Slipensky, K., Barg, M., Kondrashin, A., Zhurov, B., Zenin, A., … Fedichev, P. O. (2018). Extracting biological age from biomedical data via deep learning: too much of a good thing? Scientific Reports, 8(1), 5210. https://doi.org/10.1038/s41598-018-23534-9