Latest App Notes & Case Studies

With increased price and pressure on the helium (He) market, laboratories are looking for a more sustainable alternative to helium and exploring the option of hydrogen (H₂) carrier gas, which can be generated in the lab in a cost-effective manner and produces fast chromatography and higher sample throughput.

The cell therapy manufacturing process requires the guidance of chemical manufacturing and controls for analytical method development focusing on the critical quality attributes (CQAs).

Download this tech note to learn how mass spectrometry has gained substantial popularity for therapeutic mAb monitoring in clinical laboratories due to its great versatility to detect both tryptic peptides and intact light and heavy chains quantitatively.

The MACSima™ Imaging Platform is based on a highly multiplexed spatial proteomic technology providing a tremendous amount of complex data. MACS® iQ View – the integrated, easy-to-use analysis software – allows users to evaluate the spatial relationships of expressed markers and gain deep insights.

Rare cells play pivotal roles in disease initiation, maintenance and progression. Yet, identifying these cells remains a difficult task for low-plex technologies, as it is not always clear a priori which biomarkers distinguish rare phenotypes from the remaining population.

In drug screening, conventional high-throughput applications evaluate only a few measurements and have limited breadth to detect diverse phenotypic changes caused by compound exposure.

On the frontier of metabolic pathway analysis and fluxomics research, LC-MS and LC-TIMS-MS based isotope tracing experiments offer the opportunity to detect and quantify the incorporation of isotopically labeled atoms into an organism’s metabolites.

Lipid profiling from complex lipid extracts can be a challenging and time-consuming task. The high complexity of samples and co-elution of isobaric or isomeric compounds complicate the confident annotation of lipids.

Pyruvate kinase is an enzyme involved in energy-supplying glycolysis and ATP synthesis, thus is pivotal for the eucaryotic energy metabolism. In addition, overexpression of pyruvate kinase is believed to play a role in cancer.

Identifying a respiratory viral infection can be challenging with different families of viruses being indistinguishable during the acute phase of illness, despite the outcome and long-term prognosis of the infection being different. The ability to diagnose a respiratory virus at the initial stage of infection can result in more effective treatment for the patient.