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Using the CTC kit (CellSearch™), cells that attached to anti-EpCAM Moab were immunomagnetically separated and used for analysis of a selected pilot set of 32 genes by real time RT-PCR. This study shows the feasibility of multiple gene expression analysis on RNA isolated from only one tumor cell. Most importantly, expression analysis of several tumor-specific genes in blood samples containing only 2 tumor cells is already possible.

Pacific Northwest National Laboratory (PNNL) has developed a micro/nano particle trap that allows surface-functionalized magnetic or non-magnetic particles to be trapped with subsequent perfusion of sample, reagents and wash solutions, yielding significant (up to 5-fold) improvements in assay speed and sensitivity, while significantly reducing sample matrix effects.

Combined with extensive bioinformatics analyses, our joint analysis of transcriptomics and metabolomics data has generated interesting findings which led to further laboratory verification, such as potential genes associated with alkaloid production.

In this study we use high-speed photography as a feedback mechanism for adjusting the Nanodrop instrument dispense settings to improve the positional dispense accuracy of low volume (nanoliter) drops. These same parameters can be investigated, with various fluid classes, to reduce deleterious effects on dispensing performance such as deflected streams, satellite formation, secondary pulses and drop deformation.

HfO2 is a prospective high-k replacement for SiO2 for future integrated circuits. We study energetic of amorphous and nanocrystalline hafnium oxide by high temperature oxide melt solution calorimetry to establish critical sizes where phase stability switches by surface energy terms.

The UltraSonic Pulsed Doppler technique is a novel ultrasonic-backscatter technique for characterizing nanoparticles. Using a single transducer and able to operate in almost arbitrary vessels on samples over a range of concentrations and opacities, the system can measure concentration, size (with precision exceeding that of DLS) and mechanical compliance (for particle functionalization monitoring). To date, the system has ‘imaged’ dendrimers, colloids, carbon nanotubes, polymer beads and protein

MicroRNAs (miRNAs) comprise a recently identified class of small, non-protein-coding regulatory molecules that play important roles in many physiologic and pathologic processes, including differentiation, viral infection, and oncogenesis. In cancer, abnormal miRNA expression suggests that these molecules may serve as valuable diagnostic and prognostic molecular signatures.

New biotechnology involving nanoparticles for the production of ecologically pure vegetables in greenhouses has described. The main feature of the method is the generation of a special controlled gas medium containing nanoparticles of the main macro- and microelements, which freely penetrate into the foliage and stems of crops providing their metabolic activity. The source of the gas medium is the products of self-spreading high-temperature synthesis.

Monodisperse magnetic nanoparticles were produced and subsequently coated with a gold layer by the reduction at surface of a gold precursor in order to develop an integrated detection and “gene fishing” system. Functionalization of the nanoparticles could allow the application of this system to a variety of biomolecules.

Existence of both zircon- and monazite-type polymorphs for Dy, Tb and Gd orhtophosphates has been previously reported, however, available structural and thermodynamic data are scarce. The goal of this work was to evaluate the energetics of structural changes in these compounds.