Latest App Notes & Case Studies

Lipid nanoparticles (LNPs), comprised of ionizable lipids, are used to deliver oligonucleotides to work as therapeutics or to stimulate the immune system, as in the initial mRNA-based COVID vaccines.

Products based on mRNA have broad potential for use as therapeutics, and because mRNA leverages the translational machinery of the host cells, there is a significantly reduced risk of unwanted post-translational modifications.

Energy metabolism plays a central role in a wide variety of cellular and physiological processes. Therefore, a deep understanding of how disruption to energy metabolism impacts cells can help in therapeutic drug discovery and development.

This tech note highlights technology that switches easily between DNA and RNA analysis to ensure quick and reliable quality checks and precise sizing of DNA and IVT RNA products.

The cell therapy manufacturing process requires the guidance of chemical manufacturing and controls for analytical method development focusing on the critical quality attributes (CQAs).

Download this tech note to learn how mass spectrometry has gained substantial popularity for therapeutic mAb monitoring in clinical laboratories due to its great versatility to detect both tryptic peptides and intact light and heavy chains quantitatively.

Read how scientists at Merck KGaA use light scattering measurements to predict how formulations will behave at clinically relevant concentrations and find the optimal formulation buffer for their biologics candidates.

Glycosylation is a common post-translational modification (PTM) that plays a critical role in antibody effector functions. Comprehensive characterization of N- and O-linked glycosylation in protein therapeutics is essential for ensuring drug safety and efficacy.

Lipid nanoparticles (LNPs) comprised of ionizable lipids can be used to deliver oligonucleotides to work as therapeutics or to stimulate the immune system. Detailed and sensitive characterization of the ionizable lipid and its related impurities is necessary to ensure quality, however, obtaining the level of detail needed is challenging with current LC-MS-based methodologies.

Glycan and peptide mapping are key analytical methodologies for the structural characterization of therapeutic proteins such as monoclonal antibodies (mAbs).