Latest App Notes & Case Studies

Using genome-wide CRISPR knockout screens, followed by focused CRISPR screens, researchers at Boehringer Ingelheim probed the gene-phenotype relationship of human monocyte phagocytosis when the cells were challenged with Staphylococcus aureus.

Download this article to learn about a next-generation sequencing technology that integrates genetic and biochemical testing as well as can efficiently diagnose more than 180 metabolic diseases.

Because of this, plasmids ideally suit experimental protocols that include cloning. Inserting a piece of DNA into the linearized plasmid and generating multiple copies of the plasmid allows scientists to study DNA sequences or genes.

Comprehensive disease modeling can be challenging for many labs due to variations in reagents, cell culture conditions, technical inconsistencies across protocols and experiments and bandwidth limitations.

Single cell analysis in a spatially resolved context is the gateway to deciphering scientific questions in various application areas. Such analysis requires the highest available spatial precision combined with highly sensitive detection.

Consistent amplification uniformity during PCR is vital to making robust conclusions when comparing data obtained from wells at two different locations. But how can the effects of PCR plate consumables on amplification uniformity be mitigated?

Temperature, ramp rate and hold time are the critical parameters controlled by a thermal cycler for a successful PCR reaction, so a poor thermal cycler can negatively affect the quality of your research.

In recent years, interest in lipid nanoparticle (LNP) research has increased due to promising opportunities for RNA-based therapy and gene-editing technology, and LNPs are showing promise as nucleic acid delivery vehicles in the pharmaceutical industry.

Silica membrane-based DNA purification kits are a convenient way to prepare high quality, transfection-grade plasmid DNA samples for cloning, sequencing and restriction analysis or for more sensitive applications, such as transfection of standard cell lines.

The applications of CRISPR gene-editing technology are ever-expanding. Much of the versatility of the CRISPR system comes from the CRISPR-associated protein or Cas protein, the molecular scissors that recognize and cut specific pieces of DNA.