Latest Videos

This talk presents the discovery and optimization of potent and selective MPS1 inhibitors based on the 1H-pyrrolo[3,2-c]pyridine scaffold, guided by structure-based design and cellular characterization of MPS1 inhibition.

Metabolomics has been successfully applied to identify and validate biomarkers for congestive heart failure. Diagnosis and risk stratification of heart failure (HF) is challenging.

Jutta Eichler, University of Erlangen-Nuremberg, speaking at Discovery Chemistry Congress 2015.

There is often a debate about just how useful fragments are for well-established conventional targets such as protein kinases. Fragment screening however can be extremely valuable, providing critical ideas that lead to novelty, demonstrating how to achieve selectivity, helping dissect and make the most of HTS and literature compounds, alongside maximising ligand efficiency.

Targeted mass spectrometry, called MRM or SRM, allows for the rapid quantification of hundreds of proteins in a single assay. This tool is very specific, highly quantitative and requires very little sample (e.g. < 5 uL plasma).

Research/routine and quantitative/qualitative analyses using LC-HR-MS will be presented for drug and peptide determinations in patients’ plasma.

Despite all the progress in the proteomic and genomic research, the quantitation of steroids in biological samples is still needed for the establishment of the biochemical phenotype of disorders affecting steroid biosynthesis.

In this presentation we will explore the opportunities afforded by the hybrid magneto-plasmonic nanoparticles and PA imaging for the development of a low cost simple and nearly real-time assays for capture, separation and enumeration of rare cells.

In this talk, Martin Gijs discusses a novel magnetic surface coverage assay and a microfluidic tissue processor with applications in cancer diagnostics.