Latest App Notes & Case Studies

Target enrichment allows researchers to selectively capture, sequence and study specific genes or genomic regions. Carefully designed target enrichment probes that hybridize with high specificity and coverage are essential to ensuring workflow efficiency and data quality.

The ability to study transcript isoforms in detail could have a significant impact on our understanding of health and disease. However, most commonly, bulk sequencing is the selected method that only provides an average of the transcripts expressed across your sample of cells.

The scale of research into potential gene therapies often means that work is distributed across multiple locations. Investigators must have confidence that the results obtained at one site are consistent with results obtained at other sites participating in the study.

Single-cell RNA sequencing produces a substantial amount of complex data that can be a burden if you don’t have time to become an expert in bioinformatics.

Before you can embark on one of the many applications involving genomic DNA (gDNA), it is important to assess the quality of your samples, especially if these samples could have been exposed to physical shearing or enzymatic degradation.

RNA-based therapies can modulate cells in a controlled and targeted manner, effectively acting as gene therapies. But, as with any therapeutic, RNA therapeutics must undergo strict quality control (QC) to ensure the product is exactly as specified, with no errors or alternate products.

Traditional methods are often low throughput, time-consuming and lack linearity. However, advanced flow cytometry has emerged as a more efficient alternative for biologics development.

Routine, robust methods for long-read sequencing have the potential to allow researchers to analyze long stretches of DNA without the requirement of preamplification and can also enable analysis of complex regions that are otherwise difficult to map.

As oligonucleotides (oligos) are synthesized, small amounts of impurities can be introduced at each step, and different synthesis methods and purification efficiencies can impact the quality of the sample.

Inherited metabolic disorders (IMDs) are a vast and complex group of rare genetic diseases presenting throughout a patient’s life span.